THMC Mental Health & Innovation Centre
ADHD及腦退化評估
緻安精神健康醫療創新中心
專門診治
兒童和成人過動症及情緒病
心理健康診所
星期六下午如常應診
精準化診斷
功能性紅外線腦部掃描
(學術名稱：功能性近紅外光譜，fNIRS)
fNIRS
功能性紅外線腦掃描可以測量執行腦力任務時大腦的氧氣含量。
氧氣含量有助識別個體是處於疾病範圍(例如ADHD注意力不足過動症)還是健康範圍。
此波形還能顯示額葉和顳葉在執行腦力任務時的功能，並反映現實生活中的困難。
本診所使用的fNIRS設備已在香港衛生署醫療器材行政控制系統下列入名單
專業技術
fNIRS
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本診所使用波長780和850nm的48通道fNIRS設備測量氧合血紅素濃度。
源探測器對檢查了前額葉皮質的48個區域。
高通和低通濾波器的頻率範圍為0.005至0.1Hz，訊號雜訊閾值設定為30dB，以消除運動偽影和物理污染的機器漂移。
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基線測量指的是每次認知任務前5秒至0秒的平均血流動力學反應。
所得資料每秒採集8.138次。
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最後，將每次認知任務期間HbO2變化的平均值估算為平均血氧飽和度(HbO2)，以確定其處於健康範圍還是疾病範圍(例如：ADHD範圍)。
學術論文發表
Academic paper publications
紅外線腦部掃描技術已在何醫生參與的先前研究中得到驗證，該系統的詳細性能也在以下學術論文中提及：
Hong M, Dong SY, McIntyre RS, Chiang SK, Ho R. fNIRS Classification of Adults with ADHD Enhanced by Feature Selection. IEEE Trans Neural Syst Rehabil Eng. 2024 Dec 24;PP. doi: 10.1109/TNSRE.2024.3522121. Epub ahead of print. PMID: 40030659.
Husain SF, Chiang SK, Vasu AA, Goh CP, McIntyre RS, Tang TB, Tran BX, Dang THT, Nguyen TT, Ho RC, Ho CS. Functional Near-Infrared Spectroscopy of English-Speaking Adults With Attention-Deficit/Hyperactivity Disorder During a Verbal Fluency Task. J Atten Disord. 2023 Nov;27(13):1448-1459. doi: 10.1177/10870547231180111. Epub 2023 Jun 21. PMID: 37341192.
Chhoa KH, Chiang SK, Ong KY, Yong CK, Ng BZ, Othman SZ, McIntyre RS, Choi J, Cha J, Ho RC, Chee KY. Changes in Cerebral Hemodynamic Among Patients With Schizophrenia or Bipolar Disorder Receiving Electroconvulsive Therapy: A Task-Related Functional Near-Infrared Spectroscopy Study. J ECT. 2025 Jan 24. doi: 10.1097/YCT.0000000000001110. Epub ahead of print. PMID: 39853313.
Tran BX, Nguyen TT, Boyer L, Fond G, Auquier P, Nguyen HSA, Tran HTN, Nguyen HM, Choi J, Le HT, Latkin CA, Nathan KI, Husain SF, McIntyre RS, Ho CSH, Zhang MWB, Ho RCM. Differentiating people with schizophrenia from healthy controls in a developing Country: An evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool. Front Psychiatry. 2023 Jan 26;14:1061284. doi: 10.3389/fpsyt.2023.1061284. PMID: 36778640; PMCID: PMC9910791.
Tran BX, Nguyen TT, Nguyen HSA, Boyer L, Auquier P, Fond G, Tran HTN, Nguyen HM, Choi J, Latkin CA, Ho CSH, Husain SF, McIntyre RS, Zhang MWB, Ho RCM. Utility of portable functional near-infrared spectroscopy (fNIRS) in patients with bipolar and unipolar disorders: A comparison with healthy controls. J Affect Disord. 2023 Feb 15;323:581-591. doi: 10.1016/j.jad.2022.11.091. Epub 2022 Dec 11. PMID: 36516913.